Bayer Leverkusen claimed a 2-0 first-leg victory at Roma to take command of their Europa League semi-final.
Goals from Florian Wirtz and Robert Andrich gave the Bundesliga champions only their second win in Italy.
Roma had just two shots on target with striker Romelu Lukaku cutting an isolated figure before being replaced after 80 minutes. Substitute Tammy Abraham spurned a golden chance to reduce the arrears in stoppage time.
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